University of Michigan (1977-1982)

·        Medical pharmacology lectures to pharmacy students (Team-taught)

·        Medical pharmacology lectures to nursing students (Team-taught)

 

Morehouse School of Medicine (1982-1989)

·        Medical pharmacology for medical and graduate students (Team-taught)

 

Emory University School of Medicine (1986-1989)

·        Medical pharmacology lecture to medical students (Team-taught)

 

University of North Dakota (1989-1997)

·        Director, Medical Pharmacology I and II courses for medical students

·        Director, Drugs Subject to Abuse course for undergraduate students

·        Director, Medical Pharmacology/Basic Principles and Toxicology course for graduate students

·        Medical Pharmacology I and II courses for medical and graduate students (Team-taught)

·        Human Pharmacology course for undergraduate nursing and science students (Team-taught)

·        Principles of Pharmacology and Toxicology course for undergraduate students (Team-taught)

·        Advanced undergraduate and graduate independent readings courses

·        Medical pharmacology lectures to occupational therapy and physical therapy students (Team-taught)

·        Pharmacology and toxicology graduate courses (Team-taught)

·        Developed video "Drugs Subject to Abuse" course for Division of Correspondence Studies

·        Developed and taught "Drugs Subject to Abuse" course over North Dakota Interactive Video Network to five sites in North Dakota

 

University of Louisville (1997-present; each course is team taught)

 

·       Pharmacology and Dental Therapeutics (Course Director 2011-2022)

·       Graduate Pharmacology

·       Pharmacology for Dental Hygiene

·       Advanced Nursing Pharmacology

·       Medical Pharmacology

·       Principles of Drug and Chemical Action

·       Nursing Pharmacology

·       Environmental Science and Technology

·       Research Methods in Pharmacology and Toxicology

·       Enzymology of Foreign Compound Metabolizing Enzymes

·       Introduction to Environmental Health

·       Introduction to Epidemiology and Public Health

·       Molecular Toxicology

·       Cancer Biology

·       Summer Environmental Health Research Training Seminar Series

·       Disease and Therapeutics

·       Molecular Basis of Life, Defense, and Disease

·       Research

 

GRADUATE STUDENT THESIS/DISSERTATION TRAINING (primary mentor)

 

Master of Science

 

1.     Linda K. Thompson: Determination of Acetylation Genotypes Using Metabolites of Caffeine and Para Aminobenzoic Acid.  M.S. (Biology) Atlanta University, August 1986.

 

2.     Erik J. Furman: N-Acetylation in American Indians and other People with Diabetes Mellitus.  M.S. (Pharmacology & Toxicology) University of North Dakota, December 1993.

 

3.     Wen Jiang: N-Acetyltransferase Polymorphism and Susceptibility of Prostate Tumorigenesis.  M.S. (Pharmacology & Toxicology) University of North Dakota, August 1996.

 

4.     Kevin Gray: A Novel Procedure for the Rapid Isolation of Genomic DNA from Whole Blood and Tissues. M.S. (Pharmacology & Toxicology) University of North Dakota, May 1997.

 

5.     Adrian J. Fretland: Cloning, Sequencing, and Recombinant Expression of NAT1, NAT2, and NAT3 Derived from C3H/HeJ (Rapid) and A/HeJ (Slow) Acetylator Inbred Mouse.  M.S. (Pharmacology & Toxicology) University of North Dakota, August 1997.

 

6.     Yuanqi Zhu: Functional Characterization of NAT Gene Polymorphisms.  M.S. (Pharmacology & Toxicology) University of Louisville, December 2002.

 

7.   Yu (Janet) Zang: Mechanistic Studies on the T³⁴¹C (Ile¹¹⁴Thr) Single Nucleotide Polymorphism of Human N-acetyltransferase 2.  M.S. (Pharmacology & Toxicology) University of Louisville, December 2003.

 

8.     Kristin J. Metry: NAT Polymorphisms in Breast Cancer Risk.  M.S. (Pharmacology and Toxicology), University of Louisville, August 2004.

 

9.     Jennifer A. Loehle:  Pediatric Pharmacogenetic Studies: The Advent of Genomics, Clinical Implications, and Current Initiatives in Research.  M.S. (Pharmacology & Toxicology), University of Louisville, August 2004.

 

10.  Jason M. Walraven:  Investigations of N-acetyltransferases in Human Hepatocytes and Rat Models.  M.S. (Pharmacology & Toxicology), University of Louisville, May 2005.

 

11.  Xiaoyan (Susan) Zhang: Role of N-acetyltransferase (NAT) Polymorphism on 4, 4’-Methylene bis (2-chloroaniline) and 4, 4’-Methylenedianiline (MDA) Acetylation, MDA Hepatotoxicity and a Proposal to Study NAT Expression in Breast Cancer.  M.S., (Pharmacology & Toxicology), University of Louisville, August 2005.

 

12.  Lori M. Millner: Effect of N-acetyltransferase (NAT1) Polymorphism on Mutagenesis and DNA Adduct Formation. M.S., (Pharmacology & Toxicology), University of Louisville, May 2008.

 

13.  Thomas J. Schlierf: Role of N-acetyltransferase 1 (NAT1) and 2 (NAT2) Polymorphisms in Breast Cancer Risk with Exposure to Aromatic and Heterocyclic Amine Carcinogens.  M.S., (Pharmacology & Toxicology), University of Louisville, August 2008.

 

14.  Carmine S. Leggett: Effects of CYP1A2, NAT1, and NAT2 Genetic Variants in Nucleotide Excision Repair-deficient Human Fibroblasts: Implications for Toxicological Risk from Environmental Arylamines.  M.S., (Pharmacology & Toxicology), University of Louisville, December 2010.

 

15.  Marcus W. Stepp:  Inducible Tumor Difference Between Rapid and Slow Rat Nat2 Congenic Fischer 344 Rats Administered Methyl-Nitrosourea. M.S., (Pharmacology & Toxicology), University of Louisville, August 2014.

 

16.  Samantha M. Carlisle: Metabolomics of Transformed MDA-MB-231 Cell Lines Expressing Different Levels of Human Arylamine N-acetyltransferase 1 (NAT1).  M.S., (Pharmacology & Toxicology), University of Louisville, August 2015.

 

17.  Mariam R. Habil: N-Acetyltransferase 2 (NAT2) genotype polymorphism in cryopreserved human hepatocytes and Chinese hamster ovary (CHO) cells.  M.S., (Pharmacology & Toxicology), University of Louisville, August 2020.

 

18.  Kennedy M. Walls:  Heterocyclic Amines and Arylamine N-Acetyltransferase 2 Polymorphism in Pathogenesis of Insulin Resistance.  M.S., (Pharmacology & Toxicology), University of Louisville, May 2021.

 

Doctor of Philosophy

 

1.     Alma Trinidad: Characterization of Acetylator Genotype Dependent and Independent Hamster Hepatic N-Acetyltransferases and their Role in the Metabolism of Arylamine and N-Hydroxyarylamine Carcinogens.  Ph.D. (Biology) Clark Atlanta University, July 1989.

 

2.     Tokunbo Yerokun: The Role of Acetylator Genotype in the Expression of Urothelial N-Acetyltransferases and Genotoxic Activation of Arylamines in the Inbred Hamster System.  Ph.D. (Biology) Clark Atlanta University, July 1989.

 

3.     Ronald J. Ferguson: Syrian Inbred Hamster Arylamine N-Acetyltransferase Genes: Isolation, Functional Expression, and Characterization of Gene Products and Relationship to the N-Acetylation Polymorphism. Ph.D. (Molecular Genetics) Georgia State University, December 1994.

 

4.     Yi Feng: Hemoglobin Adducts, DNA Adducts, p53 Gene Mutations, and Aberrant Crypts Caused by 2-Aminofluorene and/or 3,2´-Dimethyl-4-Aminobiphenyl in Rapid and Slow Acetylator Syrian Hamsters Congenic at the NAT2 Locus.  Ph.D. (Pharmacology & Toxicology) University of North Dakota, May 1995.

 

5.     Anne C. Deitz: N-Acetyltransferase Genetic Polymorphisms and Breast Cancer Risk.  Ph.D. (Pharmacology & Toxicology) University of North Dakota, May 1999.

 

6.     Matthew A. Leff: Molecular Genetics of N-Acetyltransferases and Prostate Cancer.  Ph.D. (Pharmacology & Toxicology) University of Louisville, May 1999.

 

7.     Adrian J. Fretland: Pharmacogenetics of Heterocyclic Amine Carcinogenesis.  Ph.D. (Pharmacology & Toxicology) University of Louisville, May 2000.

 

8.     Yuanqi Zhu: Human NAT1 Genetic Polymorphisms: Coding Region and Non-coding Region.  Ph.D. (Pharmacology & Toxicology), University of Louisville, December 2004.

 

9.     Anwar Husain: Regulatory Control Regions of Human Arylamine N-acetyltransferase 1 and 2:  Implications for Genetic Predisposition to Breast Cancer. Ph.D. (Pharmacology & Toxicology), University of Louisville, December 2005.

 

10.  Yu (Janet) Zang: Functional Characterization and Mechanistic Studies on Single Nucleotide Polymorphisms of Human N-acetyltransferase 2.  Ph.D (Pharmacology & Toxicology), University of Louisville, May 2006.

 

11.  Kristin J. Metry (Baldauf): Role of N-acetyltransferase 2 Polymorphism in DNA Adduct Formation and Mutagenesis by Aromatic and Heterocyclic Amine Carcinogens.  Ph.D. (Pharmacology & Toxicology), University of Louisville, May 2007.

 

12.  Jason M. Walraven: Computational and Functional Analyses of Human and Rat N-acetyltransferase Genetic Variants.  Ph.D. (Pharmacology & Toxicology), University of Louisville, December 2007.

 

13.  Xiaoyan (Susan) Zhang: Characterization of N-Acetyltransferase 1 Expression in Breast Cancer.  Ph.D. (Pharmacology & Toxicology), University of Louisville, May 2008.

 

14.   Robert C.G. Martin II: Polymorphisms in Manganese Superoxide Dismutase as a Risk Factor for Cancer. Ph.D. (Pharmacology & Toxicology), University of Louisville, December 2008.

 

15.   Lori M. Millner:  Functional Analysis of N-acetyltransferase (NAT1*14B and NAT1*10) in Complete NATb and NATa mRNA.  Ph.D. (Pharmacology & Toxicology), University of Louisville, August 2011.

 

16.  Carmine S. Leggett: Role of Human Arylamine N-Acetyltransferase in Carcinogen Metabolism and Breast Cancer Progression.  Ph.D. (Pharmacology & Toxicology), University of Louisville, December 2012.

 

17.  Marcus W. Stepp: Role of Human Arylamine N-acetyltransferase 1 in Tumorigenesis and Cancer Biology. Ph.D. (Pharmacology & Toxicology), University of Louisville, December 2017.

 

18.  Samantha M. Carlisle: Deciphering the Role of Human Arylamine N-Acetyltransferase 1 in Breast Cancer Cell Metabolism Using a Systems Biology Approach. Ph.D. (Pharmacology & Toxicology), University of Louisville, August 2018.

 

19.  Mariam R. Habil:  Investigation of Human N-Acetyltransferases (NAT1 and NAT2) Genetic Polymorphisms in Susceptibility to Aromatic Amine and Alkylaniline Genotoxicity.  Ph.D. (Pharmacology & Toxicology), University of Louisville, December 2022.

 

20.  Kennedy M. Walls:  Investigation of Heterocyclic Amines and N-Acetyltransferase 2 Polymorphism in the Dysregulation of Hepatic Energy Homeostasis:  A Gene-Environment Approach.  Ph.D., (Pharmacology & Toxicology), University of Louisville, December 2023.

 

Served on over 60 additional student thesis and dissertation committees (see CV for details) 

 

POSTDOCTORAL RESEARCH TRAINING

 

1. Yi Feng, M.D., Ph.D. (1995-1996; 2003-2004)
2. Stephanie J. Webb, Ph.D. (1998-1999)
3. Udaya S. Devanaboyina, Ph.D. (1998-1999)
4. Gong H. Xiao, Ph.D. (1998-2002)
5. Matthew A. Leff, Ph.D. (1999)
6. Shuang Zhao, Ph.D. (2000-2005)
7. Jason R. Neale, Ph.D. (2003-2006)
8. Jean Bendaly, Ph.D. (2005-2008)
9. Katherine S. Bourcy, Ph.D. (2011-2013)
10. Raúl A. Salazar González, Ph.D. (2017-2022)
11. James T. F. Wise, Ph.D. (2020-2023)
12. Kennedy M. Walls, Ph.D. (2023-2024)
13. Mariam R. Habil, Ph.D. (2023- )