Joseph Moore, IVProfile page
Assoc Professor Term
School of Medicine
SPONSORED PROJECTS
- Cardiac Extracellular Matrix (ECM) Biology: Investigating how the ECM mediates communication between cardiac cells and regulates structural integrity and signaling in heart health and disease.
- Fibroblast-Driven ECM Remodeling: Exploring how fibroblasts influence ECM composition and architecture in aging, ischemic and non-ischemic cardiomyopathies, and cardiac fibrosis.
- ECM Composition, Mechanics, and Architecture: Characterizing non-fibrillar collagens, matricellular proteins, and spatial matrix organization using advanced imaging (e.g., second harmonic generation, electron microscopy) and biomechanical assays (atomic force microscopy, tensile testing).
- Mechanobiology and Pathological Signaling: Integrating structural and functional data to map how ECM remodeling alters mechanotransduction and drives pathological signaling.
- ECM-Targeted Therapeutics: Developing and testing ECM-focused interventions, such as cyclo‑RGD peptidomimetics, to disrupt aberrant fibroblast–matrix interactions and improve cardiac repair in preclinical models of myocardial infarction and pressure overload.
SPONSORED PROJECTS
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Showing page 1, sponsored projects 1 to 10 of 10
GRANT
National Institutes of Health_NIH1 Jan 2025
GRANT
National Institutes of Health_NIH12 Jan 2023
GRANT
Jewish Heritage Fund for Excellence_JHFE7 Jan 2021
GRANT
Centers for Disease Control and Prev_CDC1 Jan 2021
GRANT
National Institutes of Health_NIH4 Jan 2019
GRANT
National Heart Lung and Blood Institute1 Apr 2018 - 29 Feb 2024
People funded by this grant: MOORE IV JB
GRANT
National Institutes of Health_NIH9 Jan 2017
GRANT
National Institutes of Health_NIH9 Jan 2017
GRANT
National Institutes of Health_NIH9 Jan 2017
GRANT
National Institutes of Health_NIH9 Jan 2017