The Beverly lab is interested in using models of human cancer to elucidate the mechanisms of tumor initiation, progression and regression following therapeutic intervention.  To this end, we have adopted a philosophy of combining pre-clinical models with biochemistry, molecular biology and cultured human cells to dissect signaling pathways and cellular processes involved in all aspects of cancer biology.  Using information gathered from these experiments, we proceed back into our model systems to determine how our understanding of the disease initiation, progression or treatment response has advanced.