Since joining UofL in 1996, Dr. Koenig has co-authored over 125 articles and received over $55 million in grants from NIH-SBIR and KSTC programs, Whitaker and AHA foundations, and industry sponsors that supported development of bioinstrumentation, data acquisition and analysis systems, and MCS device testing to demonstrate efficacy and safety in compliance with Good Laboratory Practice(GLP). Our efforts with pre-clinical testing (CII) and clinical trials (Jewish Hospital) have led to successful CE Mark and FDA approval.